GRANULES
Granules
are aggregations of fine particles of powders in a mass of about spherical
shape. They typically fall within the range of 850 µm to 4.75 mm size. They are particularly suitable for the
preparation of solutions or mixtures of drugs, such as antibiotics, that are
unstable in the presence of water.
Types of Granules
1.
Sustained
release granules
These
granules are intended to be used to achieve long term action of
medicament.These are prepared on the bases of delayed time release technology.
Example
of sustained release is Zmax SR containing azithromycine sustained release
granules.
.
2.
Enteric
coated granules.
These
are made to have action in intestine by preventing dissolution in
stomach.Example Abprazole™ sachets of
enteric coated blue colored granules containing Omeprazole 25%w/w for equine
use for both the treatment and prevention of Equine Gastric Ulcers (EGUS)
3.
Effervescent
granules.
Effervescent granules
contain sodium bicarbonate and citric acid or tartaric acid in addition to the
active ingredients. On solution in water, carbon dioxide is released. These
forms mask the unpleasant taste anensure better absorption of the
medications.
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