A few
advantages of granules over powders are listed below:
1. Granules flow better than powders. The easy flow characteristics are important
in supplying drug materials from the hopper or feeding container into the
tableting presses. For this reason
powder mixtures are usually granulated if they are intended to be compressed
into tablets. Granules also eliminate or
control dust.
2.
Granules increase compressibility.
3. Granules have smaller surface area than a
comparable volume of powders. This makes granules more stable physically and
chemically than the corresponding powders.
Granules are less likely to cake or harden upon standing than are
powders.
4. Granules are more easily wetted by a solvent
than are certain powders, so that granules are also preferred in making
solutions. Example: Principen® (ampicillin) for Oral Suspension
(Squibb). Ampicillin is unstable in
aqueous solution, so it is usually prepared as granules and reconstituted by a
pharmacist with purified water just prior to dispensing. The granules also contain colorants, flavorants,
and other pharmaceutical ingredients, so the resulting solution or suspension
has all the desired medicinal and pharmaceutical features of a liquid
pharmaceutical.
5. Granules produce particle size uniformity,
thus content uniformity.
6. Can
mask the bitter taste of powder when these powders are granulated with
flavoured excepients
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