ADVANTAGES OF POWDERS
1. Powder form is the most versatile and convenient to
prescribe, compound and administer.
2. A physician has the option
to deviate from the conventional dose of a medicament according to the
requirement of the patient.
3. Powders are stable and do
not enter into reaction in solid state, lesser difficulties are experienced in
compounding them together,
4. It is possible to reduce them in the desired particle size
range and thus facilitate rapid absorption.
5. Less incompatibility as
compared to liquid dosage form.
6. Powders are in the form of
small particles; they offer a large surface area and are rapidly dissolved n
the gastrointestinal (GI) tract minimizing the problems of local irritation.
Drugs that have to be given in bulk can be best administered in powder form by
mixing them with foods or drinks.
7.Whenever effervescence is
desired, accurate quantities of the two reacting powders are mixed with water.
8. It is difficult for
children and infants to swallow tablets and capsules and under such
circumstances drugs may be administered in powder form making them palatable by
mixing with milk, fruit juice or honey.
9. Manufacturing of powder is
economic hence product cost is quite economic as compare to other dosage form.
DISADVANTAGES OF POWDERS
Powders have several disadvantages as a dosage form as described
below:
1. Patient may misunderstand the correct method of use. Without clear instruction, patients may inhale through the nose a drug intended for oral administration. In oral administration, it may have to be clear whether the drug has to be dissolved first in water or taken as is.
2. It is undesirable to take bitter or unpleasant tasting drugs by oral ad-ministration. Many herbal drugs (mainly infusions in boiling water) have very bitter tastes. To overcome the unpleasant taste of the ex-
tracts, it was often told that “bitter medicine is better medicine.” This may not necessarily be true.
3. It is difficult to protect powders containing hygroscopic, deliquescent (tending to melt or dissolve in humid environment), or aromatic materials from decomposition.
4. Uniform, individually wrapped doses of powders (sachets) are required and this may increase the manufacturing expense. (It is possible to include a spoon in a packet of powder drug. This may result in inaccurate amount of drug delivered).
5. Powder must be a homogeneous blend of all of the components and must be of the most advantageous particle size. The particle size of a drug influences the rate of solubility in water. It may also influence the biological activity of a drug.
<<<< BACK TO CALSSIFICATION OF POWDER
1. Patient may misunderstand the correct method of use. Without clear instruction, patients may inhale through the nose a drug intended for oral administration. In oral administration, it may have to be clear whether the drug has to be dissolved first in water or taken as is.
2. It is undesirable to take bitter or unpleasant tasting drugs by oral ad-ministration. Many herbal drugs (mainly infusions in boiling water) have very bitter tastes. To overcome the unpleasant taste of the ex-
tracts, it was often told that “bitter medicine is better medicine.” This may not necessarily be true.
3. It is difficult to protect powders containing hygroscopic, deliquescent (tending to melt or dissolve in humid environment), or aromatic materials from decomposition.
4. Uniform, individually wrapped doses of powders (sachets) are required and this may increase the manufacturing expense. (It is possible to include a spoon in a packet of powder drug. This may result in inaccurate amount of drug delivered).
5. Powder must be a homogeneous blend of all of the components and must be of the most advantageous particle size. The particle size of a drug influences the rate of solubility in water. It may also influence the biological activity of a drug.
<<<< BACK TO CALSSIFICATION OF POWDER
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